beta blockers

When beta-adrenergic signals stop,
synuclein expression compensates
although systolic pressure's quick to drop,
grey Lewys body gunk accumulates.
Substantia nigra's killed off year by year
asymptomatic 'til it's almost dead
until the tremors suddenly appear
and dopa must come in PO, instead.
'Though anti-hypertensives quell stage-fright
they take a toll within our CNS
musicians damping down their "fight or flight"
can compromise their motor fine finesse.
Such pharmacology's a parlous art
to balance risk, and salve to head, and heart.